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职称:副教授
学历:博士
Email: jinbiaoliu@hbut.edu.cn
研究方向:1.表观遗传修饰参与HIV潜伏和再激活的机制研究;
2. 天然免疫抗病毒感染和病毒的免疫逃逸机制。
基本情况:
刘金彪,湖北工业大学副教授,硕士生导师,2016年在武汉大学病毒学国家重点实验室获得博士学位,美国Temple大学博士后(2019-2021)。目前任职于银河yh8858com中德生物医学中心。曾任暨南大学病原微生物研究院副教授,广东省病毒学重点实验室核心成员。长期从事致病性病原微生物(冠状病毒,HIV,寨卡)感染、发病机制及诊断、免疫治疗研究。利用细胞/小鼠/非人灵长类模型,研究病毒感染与宿主免疫系统的作用机制;研究天然药物、天然免疫和表观遗传修饰在病毒感染及发病过程中的作用,为传染病的预防和治疗寻找新策略。在Journal of Medical Virology (IF=20.69), Clinical and Translational Medicine (IF=11.492), Mucosal Immunology (IF=7.31), Cell and Bioscience (IF=7.133), Frontiers in Immunology (IF=6.42)等国际权威杂志上发表高水平学术论文30余篇。主持国家自然基金、广东省自然科学基金,中央高校自主科研项目等多个项目。作为主要参与人,参加国家自然科学基金等多项课题。发明专利4项。参加第22届和26届美国神经免疫药理学会议,获得青年科学家差旅奖一等资助,并做大会报告。
有近十年生物安全高等级实验室(ABSL-3)和动物实验中心科研工作经历,熟练掌握高致病性病原微生物感染动物疾病模型的制作和相关研究工作。十分熟悉SPF级动物实验室申报、建设、管理和运营以及ABSL-3/P3/P2实验室的基础设施的建设和生物安全体系文件的撰写,对于P3/P2实验室的申报、建设、维护和使用有丰富的经验。
工作经历
2023.06至今银河yh8858com副教授
2019.04-2023.06 暨南大学病院微生物研究院副教授
2019.04-2021.06美国天普大学(Temple University)医学院博士后
科研工作
获批项目
1. 主持国家自然科学基金青年基金项目(ASH1L在HIV-1潜伏储存库形成和再激活中的作用及机制研究),21万,2019-01至2021-12;
2. 主持广东省自然科学基金面上项目(环状RNA circL3MBTL1通过翻译多肽激活HIV-1潜伏储存库的机制研究),10万,2021-01至2023-12;
3. 主持暨南大学高层次人才启动基金(HIV-1潜伏储存库清除策略),20万,2019-05至2022.04;
4. 主持国家级大学生创新创业训练计划项目(环状RNA circBRD4的鉴定及其在HIV-1潜伏再激活中的功能研究),2万,2022-06至2024-05
5. 主持中央高校基本科研业务费专项资金项目(绿茶多酚EGCG预防艾滋病毒直肠感染中国恒河猴的机制研究),15万,2017-01至2018-12;
6. 参与十二五国家传染病防治重大专项(结核潜伏感染,结核和艾滋共感染非人灵长类动物模型的研究),252.68万元2012-01至2015-12
7. 参与十二五国家传染病防治重大专项(抗艾滋病病毒的动物模型效果验证),196.82万元,2014-01至2016-12
8. 参与湖北省科技厅基础条件平台建设项目(实验动物感染技术平台的建立—艾滋、艾滋及结核共感染猕猴模型的建立),100万元,2012-01至2013-12
9. 参与国家自然科学基金面上项目(HIV和/或HCV合并感染对神经元损伤及其机制的研究),72万元,2013-01至2016-12
10. 参与国家自然科学基金面上项目(利用神经艾滋恒河猴模型研究巨噬细胞(M1/M2)激活对神经元损伤的作用和机制),70万元,2015-01至2018-12
11. 参与国家自然科学基金青年项目(γδT细胞自身免疫治疗SIV/M.tb共感染中国恒河猴的初步探讨),30万元,2014-01至2016-12
近5年论文
1. Biao Zhang#,JinBiao Liu#, Lina Zhou, Xu Wang, Shazheb Khan, Wen-Hui Hu and Wen-Zhe Ho* Cytosolic DNA Sensor Activation Inhibits HIV Infection in Macrophages.Journal of Medical Virology. 2023; 95:e28253.(IF= 20.69,中科院3区)
2. Weijie Chen, Yukun Li, Xiuling Yu, Zhenwei Wang, Wenbiao Wang, Menglan Rao, Yongkui Li, Zhen Luo, Qiwei Zhang,Jinbiao Liu*, and Jianguo Wu*. Zika virus non-structural protein 4B interacts with DHCR7 to facilitate viral infection. Virologica Sinica. 2023. 38(1): 23-33. (IF=6.95,中科院2区)
3. Nigam H Padhiar#,Jinbiao Liu#, Xu Wang, Xiaolong Wang, Brittany H Bodnar, Shazheb Khan, Peng Wang, Adil I Khan, Jin Jun Luo, Wen-Hui Hu, and Wen-Zhe Ho* Comparison of BNT162b2-, mRNA-1273- & Ad26.COV2.S- elicited IgG and Neutralizing titers against SARS-CoV-2 and its variants. Vaccines. 2022. 10(6) (IF=4.96,中科院2区)
4. Liu JB, Bodnar BH, Padhiar NH, Khan AI, Meng FZ, Saribas S, Wang P, Wang X, McCluskey E, Shah S, Zhao HQ, Luo JJ, Hu WH, Ho WZ. Correlation of vaccine-elicited antibody levels and neutralizing activities against SARS-CoV-2 and its variants.Clinical and Translational Medicine. 2021. 11(12): e644 (IF=11.492,中科院1区)
5. Liu JB, Bodnar BH, Meng FZ, Khan AI, Wang X, Saribas S, Wang T, Lohani SC, Wei ZY, Luo JJ, A, Zhou LN, Wu JG, Luo GX, Li QS, Hu WH, Ho WZ. Epigallocatechin gallate from green tea effectively blocks infection of SARS-CoV-2 and new variants by inhibiting spike binding to ACE2 receptor.Cell and Bioscience. 2021. 11(1):168. (IF=7.133,中科院2区)
6. Zheng X, Li JJ, Sheng J, Dai Y, Wang Y,Liu JB* and Xu Y,* Haplotypes of the Mutated SIRT2 Promoter Contributing to Transcription Factor Binding and Type 2 Diabetes Susceptibility, Genes, 2020, 11(5) (IF=4.096,中科院3区)
7. Sheng J, Shi WL, Guo H, Long WL, Wang YX, Qi JF,Liu JB* and Xu Y,* The inhibitory effect of (−)-epigallocatechin-3-gallate on breast cancer progression via reducing SCUBE2 methylation and DNMT activity, Molecules. 2019, 9;24. 2899. (IF=4.412,中科院3区))
8. Liu JB, Li JL, Zhuang K, Liu H, Wang X, Xiao QH, Li XD, Zhou RH, Zhou L, Ma TC, Zhou W, Liu MQ, Ho WZ, Epigallocatechin-3-gallate local pre-exposure application prevents SHIV rectal transmission in macaques.Mucosal Immunology, 2018. 11: 1230-1238 (IF=7.313,中科院1区)
9. Liu JB, Xiao QH, Zhou RH, Wang Y, Xian QY, Ma TC, Zhuang K, Zhou L, Guo DY, Wang X, Ho WZ, and Li JL. Comparative analysis of immune activation markers of CD8+ T cells in lymph nodes of different origins in SIV-infected Chinese rhesus macaques.Frontiers in Immunology, 2016. 7: 371. (IF=7.561,中科院2区)
10. Liu JB, Zhou L, Wang YZ, Wang X, Zhou Y, Ho WZ, and Li JL. Neuroprotective activity of (-)-epigallocatechin gallate against lipopolysaccharide-mediated cytotoxicity.Journal of Immunology Research, 2016. 2016: 4962351. (IF=4.818,中科院3区)
11. Yuanjun Zhu#, A. Sami Saribas#,Jinbiao Liu, Yuan Lin, Brittany Bodnar, Julia Ting, Zhengyu Wei, Kendra Ellis, Ruotong Zhao, Fang Li, Xu Wang, Xiaofeng Yang, Hong Wang, Wen-Zhe Ho and Wenhui Hu*. Protein expression/secretion boost by a novel unique 21-mer cis-regulatory motif (Exin21) via mRNA stabilization 2023.Molecular Therapy (IF= 11.454,中科院1区).
12. Meng, FZ,Liu JB, Wang X, Wang P, Hu WH, Hou W, and Ho WZ, TLR7 Activation of Macrophages by Imiquimod Inhibits HIV Infection through Modulation of Viral Entry Cellular Factors.Biology. 2021. 10(7). (IF=5.079,中科院2区)
13. Bodnar, B, Zhang YG,Liu JB, Lin Y, Wang P, Wei ZY, Saribas S, Zhu YJ, Li F, Wang X, Yang WL, Li QS, Ho WZ, and Hu WH, Novel Scalable and Simplified System to Generate Microglia-Containing Cerebral Organoids from Human Induced Pluripotent Stem Cells.Frontiers in Cellular Neuroscience, 2021. 15: 682272. (IF=5.505,中科院2区)
14. Liu, Y, Meng FZ, Wang X, Wang P,Liu JB, Hu WH, Young WB, and Ho WZ, Methamphetamine facilitates HIV infection of primary human monocytes through inhibiting cellular viral restriction factors.Cell and Bioscience, 2021. 11(1). (IF=7.133,中科院2区)
15. Liu H;Liu JB; Meng F.; Xu XQ; Wang Y; Xian QY; Zhou RH; Xiao QH; Huang ZX; Zhou L; Li JL, Li XD, Wang X, Ho WZ, and Zhuang K. CD4+ T cell depletion does not affect the level of viremia in chronically SHIV(SF162P3N)-infected Chinese cynomolgus monkeys.Virology 2021, 560, 76-85. (IF=3.61,中科院3区)
16. Wang X,Liu JB, Zhou LN and Ho WZ. Morphine withdrawal enhances HIV infection of macrophages, Frontiers in Immunology. 2019,10:2601. (IF=7.561,中科院2区)
17. Xu XQ, Liu Y, Zhang B, Liu H, Shao DD,Liu JB, Wang X, Zhou LN, Hu WH, Ho WZ. IL-22 suppresses HSV-2 replication in human cervical epithelial cells. Cytokine. 2019 123:154776 (IF=3.861,中科院3区)
18. Xu XQ, Guo L, Wang X, Liu Y, Liu H, Zhou RH, Gu J,Liu JB, Xu P, Zhou L, Ho WZ. Human cervical epithelial cells release antiviral factors and inhibit HIV replication in macrophages.Journal of Innate Immunity. 2019.11: 29-40. (IF=7.349,中科院2区)
19. Zhuang K, Zhang Y, Zhou L, Qi X, Xu XQ, Meng FZ, Xu Z,Liu JB, Shao L, Liu H, Liu H, Fang J, Deng D, Peng J, Zhou Liu. L, Tang H, Xiong Y, Ho W-Z, Guo DY, Ke H, Gui XE. Isolation and characterization of spontaneously immortalized B lymphocyte lines from HIV-infected patients with and without Non-Hodgkin's Lymphoma.Cancer Medicine. 2019. 8(15):6741-6755 (IF=4.452,中科院3区)
20. Guo L, Xu XQ, Zhou L, Zhou RH, Wang X, Li JL,Liu JB, Liu H, Zhang B, Ho WZ. Human intestinal epithelial cells release antiviral factors that inhibit HIV infection of macrophages.Frontiers in Immunology. 2018. 9: 247. (IF=7.561,中科院2区)
荣誉称号
1. 青年科学家差旅奖,26届国际神经免疫药理学协会,2020年,印度新德里,(在线会议)
2. 青年科学家差旅奖,22届国际神经免疫药理学协会,2016年,波兰克拉科夫,(大会发言)
3. 优秀学术海报奖,中南地区实验动物学会,2014年,中国武汉
4. 优秀教职工,武汉大学,2013年,中国武汉
5. 优秀教职工,武汉大学,2012年,中国武汉